Mechanisms of epigenetic deregulation in lymphoid neoplasms.

Aberrant lymphoma epigenome is the result of a combinatorial contribution of changes in DNA methylation, histone modifications, and noncoding RNA (ncRNA) expression in lymphoma cells. All of the components of epigenome have been the focus of intense studies in various subtypes of lymphoma, which resulted in the deeper understanding of novel mechanisms of lymphomagenesis and revealed novel therapeutic targets. Some of the changes are common to all lymphomas and even other types of cancers, whereas others are subtype specific. In this review, we attempt to summarize the current state of knowledge in the field of lymphoma epigenomics with particular emphasis on subtype-specific changes, differences between adult and pediatric lymphomas, and novel epigenetic therapies.